Three-Dimensional Models of the Oligomeric Human Asialoglycoprotein Receptor (ASGP-R)

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Three-Dimensional Models of the Oligomeric Human Asialoglycoprotein Receptor (ASGP-R)

The work presented here is aimed at suggesting plausible hypotheses for functional oligomeric forms of the human asialoglycoprotein receptor (ASGP-R), by applying a combination of different computational techniques. The functional ASGP-R is a hetero-oligomer, that comprises of several subunits of two different kinds (H1 and H2), which are highly homologous. Its stoichiometry is still unknown. A...

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The asialoglycoprotein (ASGP) receptor undergoes constitutive endocytosis through the coated pit/coated vesicle pathway in hepatocytes. Studies on HepG2 cells have shown that the receptor is phosphorylated at serine under control conditions and following protein kinase C stimulation. This study examined whether the ASGP receptor could also serve as a substrate for a tyrosine kinase in HepG2 cel...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2010

ISSN: 1422-0067

DOI: 10.3390/ijms11103867